منابع مشابه
Defence against bacterial drug resistance.
How does resistance arise in bacteria ? One process is simply selection; treatment with an antibiotic eliminates sensitive strains and enables an originally very small minority of resistant ones to survive and spread. This is undoubtedly what happened among staphylococci in the early days of penicillin. When exposure to a drug-antibiotic or synthetic-is followed by resistance in a previously se...
متن کاملEpigenetic Mode of Bacterial Drug Resistance
Bacterial drug resistance is one of the major factors which plays a crucial role in the treatment. Bacteria evolved various mechanisms to evade the action of these antibiotics. One of the strategies is the prevention of binding of antibiotics to ribosome through addition of methyl group favored by different methyltransferase enzymes. Ribosomal methylation leads to development of multi-drug resi...
متن کاملDrug Resistance
عفونت و تهاجم ارگانیسم های انگلی به بدن، عامل اصلی بیماری و مرگ انسانها از آغاز بشریت بوده است . در حقیقت بسیاری از اشکال حیات بدون غلبه بر ارگانیسم های زنده دیگر، قادر به ادامه زندگی نخواهند بود. انسانها معمولا مستعد تهاجم ارگانیسم های کوچکتری مانند کرمها، آمیب ها، قارچها، باکتریها و ویروسها هستند. این عوامل مکان خاصی را در بدن انتخاب کرده، مواد ضروری لازم برای حیات و تکثیر خود را دریافت نموده...
متن کاملMultidrug resistance: Versatile drug sensors of bacterial cells
One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.
متن کاملPredicting bacterial fitness cost associated with drug resistance.
OBJECTIVES It has been proposed that antimicrobial resistance could be associated with a fitness cost in bacteria, which is often determined by competition experiments between isogenic strains (wild-type and mutant). However, this conventional approach is time consuming and labour intensive. An alternative method was developed to assess the fitness cost in drug-resistant bacteria. METHODS Tim...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2003
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(03)00033-4